Just another stuck with this dreaded problem listed here, GameFAQ and gamespot forums. Stuck on loading and then PS3 reboots. It was my second playthrough once on casual on 360, then on PS3. I purchased all dlc on PS3. This was the first game I was trying to platinum and was my favorite game in 2009. I was almost there and can't bare to start from scratch and free all those serpents again.
Please take note Double Fine, this problem is real. It has nothing to do with a dirty disc or PS3 hardware from all appearances.
Please keep posting workarounds/ possible solutions here. Thanks forum.